Recombinant Human NKG2-D type II integral membrane protein (KLRK1), partial
Description
Purity > 85% as determined by SDS-PAGE. MW: 43.6kDa. Partial: 78-216aa. C-terminal FC-tagged. Homo sapiens (Human). Function as an activating and costimulatory receptor involved in immunosurveillance upon binding to various cellular stress-inducible ligands displayed at the surface of autologous tumor cells and virus-infected cells. Provides both stimulatory and costimulatory innate immune responses on activated killer cells, leading to cytotoxic activity. Acts as a costimulatory receptor for T-cell receptor in CD8+ T-cell-mediated adaptive immune responses by amplifying T-cell activation. Stimulates perforin-mediated elimination of ligand-expressing tumor cells. Signaling involves calcium influx, culminating in the expression of TNF-alpha. Participates in NK cell-mediated bone marrow graft rejection. May play a regulatory role in differentiation and survival of NK cells. Binds to ligands belonging to various subfamilies of MHC class I-related glycoproteins including MICA, MICB, RAET1E, RAET1G, RAET1L/ULBP6, ULBP1, ULBP2, ULBP3 and ULBP4.
Size
100ug
Concentration
n/a
Applications
RUO
Other Names
Killer cell lectin-like receptor subfamily K member 1 (NK cell receptor D) (NKG2-D-activating NK receptor) (CD314) (D12S2489E) (NKG2D)