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Description
Purified anti-rat CD62P (P-selectin). CD62P is a 140 kD type I transmembrane glycoprotein that is also known as P-selectin, platelet activation-dependent granule membrane protein (PADGEM), and GMP-140. It is expressed on activated platelets, megakaryocytes, and endothelial cells. CD62P is primarily stored in secretory α-granules in platelets and Weibel-Palade bodies in endothelial cells, and is rapidly relocated to the plasma membrane upon activation. The ligands for CD62P are CD162 and CD24. CD62P's primary functions are cell adhesion during neutrophil rolling, and platelet-neutrophil and platelet-monocyte interactions.
Immunogen
Thrombin activated rat platelets
Other Names
GMP-140, platelet activation-dependent granule membrane protein (PADGEM), GMP140