A cell-permeable, reversible inhibitor of Cdk1, showing preference for Cdk1/cyclin B1 (Ki = 35 nM) over Cdk1/cyclin A (Ki = 110 nM); also inhibits Cdk2 (Ki = 340 nM), PKCδ (Ki = 318 nM), and SGK (Ki = 497 nM) but not Cdk4; reversibly arrests proliferating cells at the G2/M phase border, allowing cell synchronization
Size
10 mg
Concentration
n/a
Applications
n/a
Other Names
inhibitors cells cycles cancers apoptosis inhibits inhibitions cyclin dependent cyclin-dependent kinases 1 one CDKs Cdk1 Cdk-1 one 1 Ro-3306 Ros 3306 Ro3306 cell-permeable permeable reversible Cdk1/B1 B 1 B-1 Cdk2 two 2 Cdk-2 serum glucocorticoid induces induced kinases SGKs G2/M G-2 G2 G M phases acute myeloid leukemia AMLs nutlins 3 three nutlin-3 proteins Cdk1/A cycling