Purity ~85% (SDS-PAGE). NUDT5 is a member of the nudix hydrolase family which eliminate toxic nucleotide derivatives from the cell. NUDT5 hydrolyzes ADP-ribose and ADP-mannose in the presence of magnesium, and also hydrolyzes other nucleotide sugars with low activity such as ADP-glucose and diadenosine diphosphate. As a nudix hydrolase, NUDT5 contains a central nudix motif and functions to eliminate toxic nucleotide metabolites from the cell while maintaining the levels of signaling nucleotides. NUDT5 is widely expressed but is most abundant in liver as a homodimer. Source: Recombinant corresponding to aa1-219 of human NUDT5 6x his tagged, expressed in E.coli. AA Sequence: MGSSHHHHHH SSGLVPRGSH MESQEPTESS QNGKQYIISE ELISEGKWVK LEKTTYMDPT GKTRTWESVK RTTRKEQTAD GVAVIPVLQR TLHYECIVLV KQFRPPMGGY CIEFPAGLID DGETPEAAAL RELEEETGYK GDIAECSPAV CMDPGLSNCT IHIVTVTING DDAENARPKP KPGDGEFVEV ISLPKNDLLQ RLDALVAEEH LTVDARVYSY ALALKHANAK PFEVPFLKF Molecular Weight: 26.5kD (239aa), confirmed by MALDI-TO
Size
100ug
Concentration
n/a
Applications
n/a
Other Names
NUDT5, aa1-219, Recombinant, Human (ADP-sugar Pyrophosphatase, HSPC115, hYSAH1, Nucleoside Diphosphate-linked Moiety X Motif 5, Nudix Motif 5, YSA1H)