Phloretin is a natural phenol which inhibits a variety of transporters. It inhibits the monocarboxylate transporters MCT1 and MCT2 (IC50 = 28 and 14 μM, respectively), restricting the rapid transport of monocarboxylates like lactate and pyruvate across the plasma membrane. Phloretin also blocks the sodium/D-glucose cotransporter (Ki = 86 μM) and the human concentrative nucleoside transporter 3 (Ki = 32 μM). Blocks L-type Ca?+ channels; activates Ca?+-activated K+ channels in amphibian myelinated nerve fibers. MW: 274.27. Purity ≥98% by HPLC