A potent inhibitor of several CDKs with selectivity for Cdk2 (IC50s = 22, 40, and 200 nM for Cdk2/cyclin A, Cdk1/cyclin B, and Cdk4/cyclin D1); has anti-proliferative and pro-apoptotic activity in tumor cells
Size
5 mg
Concentration
n/a
Applications
n/a
Other Names
Cdk2 apoptosis cancers cyclins inhibitors leukemias pRb retinoblastomas proteins cells cycles SU9516 SU-9516 SU 9515 3-substituted indolinones 3 substituted anti-proliferatives anti proliferatives antiproliferatives pro-apoptotic proapoptotic pro apoptotic activity activities active tumors cyclin-dependent dependent kinases CDKs Cdk-2 2 two Cdk1 Cdk-1 1 one A B D1 cyclin-D1 cyclin-A cyclin-B retinoblastomas pRb cell-cycles arrests U-937 U 937 U937 jurkat HL-60 HL60 HL 60 Mcl1 Mcl-1 Mcl 1 mitochondrial mitochondrias injuries injury deaths inhibits inhibitions Cdk4 Cdk-4 4 Cdk2/cyclin Cdk1/cyclin Cdk4/cyclin 3 three substituted PKC p38 PDGFR EGFR phosphorylations pRb/E2F complexes formations downregulates downregulation transcriptions