Recombinant Human coronavirus OC43 Spike glycoprotein (S), partial
Description
Purity > 90% as determined by SDS-PAGE. MW: 39.6kDa. Partial: 15-344aa. N-terminal 6xHis-tagged. Human coronavirus OC43 (HCoV-OC43). S1 attaches the virion to the cell mbrane by interacting with sialic acid-containing cell receptors, initiating the infection.S2 is a class I viral fusion protein. Under the current model, the protein has at least 3 conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and target cell mbrane fusion, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell mbranes.