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| Antigenic Specificity | PTCH2 |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | human, mouse (predicted: hamster) |
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| Isotype | n/a |
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| Format | immunogen affinity purified |
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| Size | 100ug (sample available) |
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| Concentration | 500ug/ml. |
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| Applications | WB |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | Rabbit IgG polyclonal antibody for Protein patched homolog 2(PTCH2) detection. Tested with WB in Human;Mouse. No cross reactivity with other proteins. PTCH2(patched 2), also known as PTC2, encodes a 1.203-amino acid putative transmembrane protein that is highly homologous to the PTCH product. The Patched-hedgehog signaling pathway is involved in establishing segment polarity and the anterior-posterior orientation of a number of developing appendages. The pathway is conserved from fly to vertebrates and has been implicated in a number of human neoplasms and developmental syndromes. Mutations in the human Patched gene are the basis of the nevoid basal cell carcinoma syndrome. With age, homozygous mutant male mice developed skin lesions consisting of alopecia and epidermal hyperplasia, suggesting a role for Ptch2 in adult epidermal homeostasis via Shh signaling. |
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| Immunogen | A synthetic peptide corresponding to a sequence at the C-terminus of human PTCH2(885-901aa WLHDKYDTTGENLRIPP), different from the related mouse sequence by one amino acid. |
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| Other Names | Protein patched homolog 2;PTC2;PTCH2;UNQ560/PRO1121/PRO57079; |
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| Gene, Accession # | PTCH2, UniProt: Q9Y6C5 |
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| Catalog # | PA1859 |
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| Price | |
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| Order / More Info | PTCH2 Antibody from BOSTER BIO |
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| Product Specific References | n/a |
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