An endogenous peptide with diverse biological activities; a selective agonist of NPR2 and 3 (Kds = 7, 10.8, and >500,000 pM for NPR2, 3, and 1, respectively); stimulates cGMP accumulation in HEK293 cells expressing rat NPR2 (ED50 = 2.2 nM) and relaxes isolated rat cerebral arterioles (EC50 = 0.52 nM); (25 μg/kg) decreases kidney injury and oxidative and inflammatory responses in a rat model of hemorrhagic shock (25 μg/kg)