Purity > 90% as determined by SDS-PAGE. MW: 38.6kDa. Extracellular Domain: 210-424aa. N-terminal 6xHis-B2M-tagged. Rattus norvegicus (Rat). Constitutive NADPH oxidase which generates superoxide intracellularly upon formation of a complex with CYBA/p22phox. Regulates signaling cascades probably through phosphatases inhibition. May function as an oxygen sensor regulating the KCNK3/TASK-1 potassium channel and HIF1A activity. May regulate insulin signaling cascade. May play a role in apoptosis, bone resorption and lipolysaccharide-mediated activation of NFKB.