Immunohistochemistry (Paraffin): 1:150, Western Blot: 1:4000
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Description
SERPINB3 Monoclonal Antibody (OTI1A12). Metastasis of a primary tumor to a distant site is determined through signaling cascades that break down interactions between the cell and extracellular matrix proteins. Among the proteins mediating metastasis are serine prote-ases, such as neutrophil elastase. In 1985, Dr. Jim Travis and Dr. R.W. Carrell designated an emerging family of serine protease inhibitors as the serpin fam-ily, which share homology in both primary amino acid sequence and tertiary structure. Serpins contain a stretch of peptide that mimics a true substrate for a corresponding serine protease. Serine proteases bind to this substrate mimic in a 1:1 stoichiometric fashion and become catalytically inactive. Aberrant ex-pression of
Immunogen
n/a
Other Names
HsT1196, SCC, SCCA-1, SCCA-PD, SCCA1, T4-A, protein T4-A, serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 3, serpin B3, squamous cell carcinoma antigen 1