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Description
Platelet-derived endothelial growth factor (PD-ECGF), same as thymidine phosphorylase (TP) or gliostatin. In the presence of inorganic orthophosphate, it catalyses the reversible phospholytic cleavage of thymidine and deoxyuridine to their corresponding bases and 2-deoxyribose-1-phosphate. It is both chemotactic and mitogenic for endothelial cells and a non-heparin binding angiogenic factor present in platelets. It is also involved in transformation of fluoropyrimidines, cytotoxic agents used in the treatment of a variety of malignancies, into active cytotoxic metabolites.Synonyms: ECGF1, Gliostatin, PD-ECGF, Platelet-derived endothelial cell growth factor, TdRPase
Immunogen
Recombinant full length human thymidine phosphorylase (TP/PD-ECGF) protein.