Mesencephalic Astrocyte-Derived Neurotrophic Factor (MANF) (AA 25-182) protein (His tag)
Description
MANF also called ARMET or ARP, is short for Mesencephalic astrocyte- derived neurotrophic factor. It is a 182 aa. protein with a 24 aa. signal peptide. The N-terminal region of MANF may be responsible for neurotrophic activity while the C-terminal region may play a role in the ER stress response. It is secreted and can be inducted by endoplasmic reticulum stress. This protein selectively promotes the survival of dopaminergic neurons of the ventral mid-brain, and can modulates GABAergic transmission to the dopaminergic neurons of the substantia nigra. It also enhances spontaneous, as well as evoked, GABAergic inhibitory postsynaptic currents in dopaminergic neurons and inhibits cell proliferation and endoplasmic reticulum (ER) stress-induced cell death.