Purity > 90% as determined by SDS-PAGE. MW: 23.5kDa. Full Length of Mature Protein: 20-85aa. N-terminal 6xHis-SUMO-tagged. Leiurus quinquestriatus hebraeus (Yellow scorpion). Alpha toxins bind voltage-independently at site-3 of sodium channels (Nav) and inhibit the inactivation of the activated channels, thereby blocking neuronal transmission. The dissociation is voltage-dependent. This toxin is active on insects. It is also highly toxic to crustaceans and has a measurable but low toxicity to mice.