WAP four-disulfide core domain protein 2, also known as Human Epididymis Protein 4 (HE4), is a protein that in humans is encoded by the WFDC2 gene. This gene encodes a protein that is a member of the WFDC domain family. The WFDC domain, or WAP Signature motif, contains eight cysteines forming four disulfide bonds at the core of the protein, and functions as a protease inhibitor in many family members. This gene is expressed in pulmonary epithelial cells, and was also found to be expressed in some ovarian cancers. The encoded protein is a small secretory protein, which may be involved in sperm maturation. Sample Type: Serum, urine, cell culture supernates, saliva, human milk, plasma (Heparin or EDTA). Intended Use: Sandwich High Sensitivity BioAssay? ELISA kit for Quantitative Detection of Human HE4. Sensitivity: <15pg/ml Range: 156pg/ml-10,000pg/ml Specificity: Recognizes natural and recombinant Human HE4. There is no detectable cross-reactivity with other relevant proteins. Test Princ