Tumor Necrosis Factor (Ligand) Superfamily, Member 9 (TNFSF9) (Active) protein
Description
CD137L or 4-1BBL, a member of the TNF superfamily, is expressed in B cells, dendritic cells, activated T cells and macrophages. 4-1BBL binds to its receptor 4-1BB, and provides a co-stimulatory signal for T cell activation and expansion. The human 4-1BBL gene codes for a 254 amino acid type II transmembrane containing a 28 amino acid cytoplasmic domain, a 21 amino acid transmembrane domain, and a 205 amino acid extracellular domain. The soluble form of 4-1BBL contains the TNF-like portion of the extracellular domain of 4-1BBL. Alternative Names: TNFSF9 protein, CDL-137 protein, CDL 137 protein, 4-1BB protein, CDL-137, CD137L, CDL 137