A selective SIP1 agonist (EC50 = 1.35 nM); activates S1P1-mediated p42/p44 MAPK phosphorylation in CHO-K1 cells transfected with S1P1 (EC50 = 46 nM); induces S1P1-dependent lymphopenia in mice, decreasing B and T cells by 65 and 85%, respectively, at 50 nM
Size
5 mg
Concentration
n/a
Applications
n/a
Other Names
agonist SIP1 receptor sphingosine-1-phosphate S1P lipid mediator lymphocyte vascular research EDG-1 biochemical ceramide sphingolipid biochemistry signal transduction immunology disease CYM5442