Purity >98%. Activation of latent reservoirs of HIV-infected cells is a treatment strategy designed to reduce viral load and eliminate the perpetuation of retroviral infection. Prostratin is a non-tumor promoting phorbol ester that potently induces HIV-1 reactivation in latent reservoirs of infected Jurkat-LAT-GFP cells with an IC50 value of ~0.5 μM. Originally, prostratin was isolated from plant sources including P. prostrata, E. cornigera, and H. nutans . 2 The effects of prostratin are mediated through activation of NF-?B via protein kinase C and by downregulation of HIV-1 receptor CD4 expression and its co-receptors CXCR4 and CCR5.
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Other Names
9a-(acetyloxy)-1,1aR,1bS,4,4aR,7aS,7bR,8R,9,9aS-decahydro-4a,7b-dihydro-3-(hydroxymethyl)-1,1,6,8-tetramethyl-5H-cyclopropa[3,4]benz[1,2-e]azulen-5-one, 13-O-Acetylphorbol, NSC 623310, SA 101A