1-29aa, Partial. MW: 33.3 kDa. Purity >85% as determined by SDS-PAGE. High affinity receptor for N-formyl-methionyl peptides (FMLP), which are powerful neutrophils chemotactic factors. Stimulate chemotaxis in immune cells to site of infection or tissue damage upon recognition of several ligands, such as FMLP, or ligand involved in cell damage, disease or inflammation.
N-formylpeptides induce two distinct concentration optima for mouse neutrophil chemotaxis by differential interaction with two N-formylpeptide receptor (FPR) subtypes. Molecular characterization of FPR2, a second mouse neutrophil FPR. Hartt J.K., Barish G., Murphy P.M., Gao J.L. J. Exp. Med. 190:741-747(1999)