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Description
Purified anti-CD106 (VCAM-1). CD106 is a 110 kD single chain type I glycoprotein, which is also known as VCAM-1 and INCAM-110. It is expressed predominantly on activated vascular endothelium but has also been identified on follicular and interfollicular dendritic cells, some macrophages, bone marrow stromal cells, and non-vascular cell populations within joints, kidney, muscle, heart, placenta, and brain. Expression on endothelial cells as well as many other cells is induced by inflammatory stimuli and cytokines. Activated endothelial cells can release soluble forms of CD106 which can be detected in the blood. CD106 binds the integrins CD49d/CD29 (VLA-4) and α4β7 that contribute to leukocyte adhesion, transmigration, and co-stimulation of T cell proliferation.
Immunogen
The P3C4 monoclonal antibody was generated against IL-1β activated human umbilical vein endothelial cells (HUVECs).
Other Names
Vascular cell adhesion protein 1, CD106 antigen, MMS-476P-100