If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY.
Description
Purified anti-CD49e (Integrin α5). CD49e is a type I integral membrane glycoprotein, known as α5 integrin, or VLA-5 α chain. It forms noncovalent heterodimer with integrin β1 (CD29). CD49e contains two disulfide-linked subunits of 135 kD and 24 kD, and is mainly expressed on thymocytes, activated lymphocytes, endothelial cells, osteoblasts, melanoma, and some myeloid leukemia cells. CD49e/CD29 complex binds to fibronectin and neural adhesion molecule L1. It mediates monocytes migration, it is involved in the regulation of cells survival and apoptosis, and co-stimulates T cell activation.
Immunogen
The P1D6 monoclonal antibody was generated against human HT1080 fibrosarcoma cells and reacts with the α5 integrin subunit.
Other Names
FNRA, VLA5A, Integrin alpha-5, VLA-5, integrin alpha-F, CD49 antigen-like family member E, fibronectin receptor subunit alpha, very late activation protein 5, alpha subunit