Purified (~70-90%). MARK1 is a member of the MARK family and is a serine/threonine-protein kinase that plays a key role in signal transduction. Due to its protein serine/threonine kinase activity, MARK1 is known to mediate phosphorylation of key proteins involved in signal transduction and cell communication. MARK1 phosphorylates microtubule-associated proteins and trigger microtubule disruption. Gene mutation studies performed in mice revealed that after targeted disruption of the MARK1 gene, the mice lacked the ability to drink, and displayed hind leg motor dysfunction. Source: Recombinant protein corresponding to human MARK1 fused to GST-Tag at N-terminal expressed in Insect cells. Molecular Weight: ~125kD Specific Activity: 470nmol/min/mg as per activity assay protocol. Endotoxin: <1EU/ug (LAL)