If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY.
Description
Reacts with α 3 integrin, a 150 kDa transmembrane glycoprotein which non-covalently associates with integrin b 1 (CD 29) to form the α 3b1 (CD49c/CD29,VLA-3) complex. CD49c is expressed mostly on endothelial and epithelial cells (basal epidermal layers). It is not expressed on platelets and is expressed weakly on peripheral blood leukocytes. The CD49c/CD29 complex serves as an adhesive receptor for kalinin or epiligrin. This interaction may be important for thymocyte interaction with thymic epithelium. This antibody is suitable for immunohistochemical staining on acetone-fixed frozen tissue sections.1-3. It is a type I transmembrane glycoprotein which is proteolytically cleaved into two disulfide linked fragments of 125 kD and 30 kD. CD49c forms a heterodimer with integrin b1 (α3b1, CD49c/CD29, VLA-3) and is expressed by many types of adhesion cells, such as endothelial cells, epithelial cells, and dermal fibroblasts. Weak expression has been reported on leukocytes. VLA-3 plays a role in cell-cell and cell-matrix adhesion through binding Kalinin, collagen, laminin-1, laminin-5, entactin, and fibronectin.
Immunogen
Integrin alpha 3.
Other Names
CD49c; Integrin alpha-3; CD49 antigen-like family member C; FRP-2; Galactoprotein B3; GAPB3; VLA-3 subunit alpha; MSK18; VCA-2; VL3A; VLA3a