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Description
The monoclonal antibody is directed against the CD49b- antigen (GP Ia or VLA-2 alpha-chain), which can form distinct complexes with either the CD29-antigen (GP IIa or VLA beta-chain), resulting in the VLA-2 (alpha-2 beta- 1) complex, which is expressed on human platelets. The monoclonal antibody reacts with platelets, long-term cultivated T lymphocytes and activated T lymphocytes. In immunohistology the monoclonal antibody reacts with thymocytes, epithelial cells of a variety of tissues, peripheral nerves, fibroblasts, osteoclasts, glomerular mesangium and most non-haemopoietic adherent cell lines. Human platelet antigen (MW 170kDa). The antigen is found on platelets, endothelial cells and approximately 50% of monocytes together with activated T cells. The gpla antigen is non- covalently associated with the 130kD VLA β-chain (CD29) in the VLA-2 complex.
Immunogen
Integrin alpha 2.
Other Names
CD49b; Integrin alpha-2; CD49 antigen-like family member B; Collagen receptor; Platelet membrane glycoprotein Ia; GPIa; VLA-2 subunit alpha; BR; VLAA2; VLAA3; VLAA4; VLAA5; VLAA6; VLA alpha-2 chain (Collagen Receptor); MAB TO CD49B