Purity > 90% as determined by SDS-PAGE. MW: 62.9kDa. Partial: 25-554aa. N-terminal 6xHis-tagged. Rattus norvegicus (Rat). Plays a key role in secretory granule-dependent cell death, and in defense against virus-infected or neoplastic cells. Can insert into the mbrane of target cells in its calcium-bound form, oligomerize and form large pores. Promotes cytolysis and apoptosis of target cells by facilitating the uptake of cytotoxic granzymes.