1-111aa; Full Length. MW: 39.4kD. Purity >90% as determined by SDS-PAGE. PCNA-binding protein that acts as a regulator of DNA repair during DNA replication. Following DNA damage, the interaction with PCNA is disrupted, facilitating the interaction between monoubiquitinated PCNA and the translesion DNA synthesis DNA polymerase eta (POLH) at stalled replisomes, facilitating the bypass of replication-fork-blocking lesions. Also acts as a regulator of centrosome number.
[Hepatitis C virus NS5 A-transactivated protein 9; HCV NS5A-transactivated protein 9; Overexpressed in anaplastic thyroid carcinoma 1; OEATC-1; PCNA-associated factor of 15 kDa; PAF15; p15PAF]
Cloning and identification of human gene 9 transactivated by hepatitis C virus NS5A protein.Liu Y., Cheng J., Wang G., Wang J., Zhang L., Chen J., Li L.Suppression subtractive hybridization and expression profiling identifies a unique set of genes overexpressed in non-small-cell lung cancer.Petroziello J., Yamane A., Westendorf L., Thompson M., McDonagh C., Cerveny C., Law C.-L., Wahl A., Carter P.Oncogene 23:7734-7745(2004) KIAA0101 is overexpressed, and promotes growth and invasion in adrenal