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Description
FUNCTION: Component of heterochromatin. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. Interaction with lamin B receptor (LBR) can contribute to the association of the heterochromatin with the inner nuclear membrane. SUBCELLULAR LOCATION: Nucleus. Note: Unassociated with chromosomes during mitosis. Tissue specificity: Expressed in all adult and embryonic tissues.Synonyms: Chromobox protein homolog 1, HP1Hsbeta, Heterochromatin protein 1 homolog beta, HP1 beta, Heterochromatin protein p25, M31, Modifier 1 protein, p25beta
Immunogen
A synthetic peptide from aa region 50-100 of human CBX1 conjugated to an immunogenic carrier protein was used as the antigen.