If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY.
Description
CBX4 is a member of Drosophila Polycomb group gene family. The polycomb group (PcG) genes are essential for maintenance of proper expression patterns of developmental master regulators, changes in expression pf PcG proteins have been associated with cancer. CBX4 is a part of the cellular memory system responsible for the inheritance of gene activity by progeny cells. It participates in maintaining the transcriptionally repressive state of genes. CBX4 is part of acomplex that acts via chromatin remodeling and modification of histones, it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. CBX4 is an E3 SUMO-protein ligase which facilitates SUMO1 conjugation by UBE2I.Synonyms: Chromobox protein homolog 4, E3 SUMO-protein ligase CBX4, Polycomb 2 homolog
Immunogen
This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the N-terminal region of human CBX4.