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Description
PDCD12 (Programmed cell death 12), also referred to as AVEN, represents a new class of cell death regulator. PDCD12 is a conserved intracellular membrane protein that blocks apoptosis impeded by Apaf-1 mediated caspase activation. Bcl-2 and BAD also interact with PDCD12 to prevent apoptosis. It is expressed in a wide variety of normal tissues including heart, skeletal muscle, kidney, liver, testis, and diseases such as cancer
Immunogen
Recombinant human PDCD12 (254-362aa) purified from E. coli
Other Names
cell death regulator aven, apoptosis, caspase activation inhibitor, PDCD12, programmed cell death 12