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Description
The monoclonal antibody R63 reacts with the rat receptor for C5a (CD88). The rat anaphylatoxin C5a is a 77-amino acid glycopolypeptide which is generated by proteolytic cleavage of the complement factor C5 in the course of complement activation. A variety of biological effects evoked by C5a has been demonstrated, rendering this molecule an important mediator of inflammation, with granulocytes and macrophages as the main target cells. All cellular responses to C5a are specifically mediated by interactions with the membrane bound C5a receptor, a seven transmembrane GTP-binding-protein- coupled receptor that belongs to the rhodopsin supergene family. The 45 kDa C5a receptor is expressed by myeloid cells including Kupfer cells. Using immunohistology there is no evidence for non-myeloid expression in healthy control rats. Under inflammatory situations however the C5aR was found to be upregulated in various organs and tissues including the liver. Aliases C5aR, CD88, C5a anaphylatoxin chemotactic receptor, C5a anaphylatoxin receptor, C5a ligand, C5a- R, complement component 5a receptor 1 Immunogen RBH-2H3 cells transfected with rat C5aR gene