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Description
The protein encoded by this gene contains a RING zinc finger, a motif known to be involved in protein-protein interactions. This protein interacts with androgen receptor (AR) and may function as a coactivator that induces AR target gene expression in prostate. A dominant negative mutant of this gene has been demonstrated to inhibit the AR-mediated growth of prostate cancer. This protein also interacts with class III ubiquitin-conjugating enzymes (E2s) and may act as a ubiquitin-ligase (E3) in the ubiquitination of certain nuclear proteins. Five alternatively spliced transcript variants encoding two distinct isoforms have been reported. This RNF14 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 336-364 amino acids from the C-terminal region of human RNF14.
Immunogen
Human RNF14.
Other Names
androgen receptor associated protein 54; Androgen receptor-associated protein 54; ARA54; E3 ubiquitin-protein ligase RNF14; FLJ26004; HFB30; HRIHFB2038; RING finger protein 14; RNF14; TRIAD2; Triad2 protein