A lipoic acid analog that inhibits α-ketoglutarate dehydrogenase, particularly in tumor cells; induces a strong mitochondrial burst of reactive oxygen species at 60-240 μM, resulting in cell death; demonstrates both in vitro and in vivo anti-tumor activity
Size
50 mg
Concentration
n/a
Applications
n/a
Other Names
biochemical inhibitor cancer metabolism apoptosis mitochondrial biology CPI613 inhibit α-ketoglutarate dehydrogenase αketoglutarate lipoic acid analog tumor cells burst reactive oxygen species death in vivo in vitro antitumor anti-tumor apoptotic nonapoptotic pathway