If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY.
Description
Function: Receptor for endothelin-1. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of binding affinities for ET-A is: ET1 > ET2 >> ET3.Tissue specificity: Isoform 1, isoform 3 and isoform 4 are expressed in a variety of tissues, with highest levels in the aorta and cerebellum, followed by lung, atrium and cerebral cortex, lower levels in the placenta, kidney, adrenal gland, duodenum, colon, ventricle and liver but no expression in umbilical vein endothelial cells. Within the placenta, isoform 1, isoform 2, isoform 3 and isoform 4 are expressed in the villi and stem villi vessels.Subcellular location: Cell membrane, Multi-pass membrane protein. Also known as: EDNRA, Endothelin A receptor, ET-A, ETA-R, ETA, ETRA.
Immunogen
A synthetic peptide from c-terminal region of human Endothelin-1 receptor (EDNRA) conjugated to an immunogenic carrier protein was used as the antigen.