EZClick? TUNEL - in situ DNA Fragmentation/Apoptosis Assay Kit
Description
Apoptosis is a controlled phenomenon in which apoptotic cells are characterized by changes in nucleus (i.e. chromatin condensation, DNA fragmentation), cytoplasm shrinkage and production of apoptotic bodies. These are subsequently phagocytosed by macrophages, parenchymal cells, or neoplastic cells. DNA strand breaks can be analyzed by TUNEL (Terminal deoxynucleotidyl transferase dUTP Nick End-Labeling) assays. BioVision's EZClickTM TUNEL-DNA fragmentation/Apoptosis Assay utilizes modified EdUTP nucleotides which are incorporated at the 3'-OH ends of fragmented DNA by Terminal deoxynucleotidyl transferase (TdT) enzyme and detected based on a click reaction. This assay enables easy delivery and incorporation of EdUTP coupled with high selecti
Size
100 assays
Concentration
n/a
Applications
Detection of DNA fragmentation during apoptosis and programmed cell death,Evaluating effects of anti-cancer drugs and genotoxic agents on DNA structure,Screening for genotoxic compounds and effectors of DNA integrity and cellular changes,In-situ studies of apoptosis and programmed cell death