Purity >98%. Apoptozole is an inhibitor of heat shock protein 70 (Hsp70; 65% inhibition at 200 μM) that acts by blocking its ATPase activity. It does not act on Hsp40, Hsp60, or Hsp90. Apoptozole dose-dependently induces apoptosis in cancer cells (IC50 = 5-7 μM). It prevents the association of Hsp70 with apoptotic protease-activating factor 1 and triggers caspase activation in HeLa cells. Apoptozole (10 mg/kg, i.p.) prevents the growth of A549, RKO, and HeLa cell xenografts in mice without significant loss of body weight.
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Other Names
4-[[2-[3,5-bis (trifluoromethyl)phenyl]-4,5-bis (4-methoxyphenyl)-1H-imidazol-1-yl]methyl]-benzamide, Apoptosis Activator VII