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Description
The epidermal growth factor (EGF)-TM7 family constitutes a group of class B G-protein coupled receptors, which includes CD97, EMR1 (EGF-like molecule containing mucin-like hormone receptor 1, designated F4/80 in mouse), EMR2, EMR3, FIRE, and ETL (1i?1/23). These family members are characterized by an extended extracellular region with several N-terminal EGF domains, and are predominantly expressed on cells of the immune system (1i?1/23). The EGF-TM7 protein family are encoded by a gene cluster on human chromosome 19p13 . The F4/80 molecule is solely expressed on the surface of macrophages and serves as a marker for mature macrophage tissues, including Kupffer cells in liver, splenic red pulp macrophages, brain microglia, gut lamina propria, and Langerhans cells in the skin . F4/80/EMR1 undergoes extensive N-linked glycosylation as well as some O-linked glycosylation . The function of F4/80/EMR1 is unclear, but it is speculated to be involved in macrophage adhesion events, cell migration, or as a G-protein coupled signaling component of macrophages . Synonyms: Emr1,DD7A5-7,EGF-TM7,F4/80,Gpf480,Ly71,TM7LN3 ,