Tumor Necrosis Factor Receptor Superfamily, Member 1B (TNFRSF1B)
Clone
polyclonal
Host Species
Rabbit
Reactive Species
mouse, rat, human
Isotype
n/a
Format
affinity purified
Size
100 μg
Concentration
n/a
Applications
Western Blotting (WB),Immunohistochemistry (IHC)
Reviews / Ratings
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Description
TNF-alpha is an important cytokine produced by numerous cell types including neutrophils, activated lymphoctyes, macrophages an NK cells. It plays a critical role in inflammatory responses and in apoptosis. TNF-alpha exists as a membrane-anchored and soluble form, both of which show biological activity. Response to TNF-alpha is mediated through two receptors, TNF-R1, which is widely expressed, and TNF-R2, which is expressed mainly in immune and endothelial cells. Antagonists to TNF-alpha have been validated as therapeutic targets for rheumatoid arthritis and other immune disorders. The two receptors for TNF-alpha, TNF-R1 (55 kDa) and TNF-R2 (75 kDa) can mediate distinct cellular responses. In most cases cytotoxicity elicited by TNF has been reported to act throught TNF-R1. In contrast, TNF-R2 appears to be important in T cell signaling and responses to infection. TNF-R2 binds to distinct members of the TRAF family leading to the activation of NF-kappaB. Soluble forms of both receptors have also been characterized which can bind TNF-alpha and may play an important role in immune disorders.Synonyms: TNFRSF1B, CD120b, TBPII, TNF-R-II, TNF-R75, TNFBR, TNFR1B, TNFR2, TNFR80, p75, p75TNFR