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Description
Ultra-LEAF? Purified anti-mouse CD95 (Fas). CD95, also known as Fas, is an approximately 45 kD type I transmembrane protein belonging to the TNFR superfamily (TNFRSF6). The expression of CD95 has been described in various organs, such as thymus, spleen, liver, heart, lung and ovary. Upon ligand (FasL) binding, CD95 forms the death-inducing signaling complex (DISC) intracellularly and induces apoptosis of the cell. CD95-induced apoptosis plays important roles in development, as well as in maintaining peripheral tolerance of the immune system.