An isoflavone; binds to ERβ (Ki = 2.8 μM) but not ERα up to 1 mM; estrogenic in vitro, increasing ERE-mediated gene transcription via ERβ (EC50 = 2.8 μM); an inhibitor of CAVII and CAXII (Kis = 4.2 and 56 nM, respectively) and selective for them over CAI, II, and IV (Kis = >10,000, >10,000, and 718.7 nM, respectively); reduces tumor growth in a PC3 prostate cancer mouse orthtopic model at 50 mg/kg per day