Insulin-Like Growth Factor Binding Protein 7 (IGFBP7) protein
Description
IGF-BPs controls the distribution, function and activity of IGFs in various cell tissues and body fluids. Currently there are seven named IGF-BPs that form high affinity complexes with both IGF-I and IGF-II. IGF-BP7 is expressed in a wide range of normal human tissues and it generally shows reduced expression in cancer cell lines of prostate, breast, colon, and lung origin. It plays a role in skeletal myogenesis by binding to IGF1n a manner that inhibits IGF1nduced differentiation of skeletal myoblasts, without affecting IGF1nduced proliferation. Alternative Names: IGF binding protein related protein-1 protein, IGF BP 7, IGF BP-7, Mac25 protein, IGF BP-7 protein, IGF BP7, Insulin-like growth factor binding protein-7 protein, IGFBPrP1 protein, IGF BP 7 protein, IBP-7 protein, IGF BP-7 protein