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Description
Rabbit Anti-Human LRWD1 polyclonal antibody for IHC, ICC. Leucine-rich repeat and WD repeat-containing protein 1, also known as, ORC-associated protein or ORCA or Origin recognition complex-associated protein, and encoded by the gene name(s), LRWD1 or ORCA, is associated component of the origin recognition complex (orc required to recruit and stabilize the orc complex to chromatin). Probably required for the association of orc on chromatin during g1 to establish pre-replication complex (prerc and to heterochromatic sites in post-replicated cells). Binds a combination of dna and histone methylation repressive marks on heterochromatin: binds histone h3 and h4 trimethylation marks h3k9me3;h3k27me3 and h4k20me3 in a cooperative manner with dna methylation. It is unclear whether it recognizes and binds these repressive marks by itself or needs additional factors.