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Description
Rabbit Anti-Mouse AXIN1 polyclonal antibody for WB, IF. Axin-1 (UniProt P57094; also known as Axis inhibition protein 1, Protein Fused) is encoded by the Axin1 (also known as Axin, Fu) gene (Gene ID 12005) in murine species. The expansion of the mammalian cerebral cortex is controlled by a balance between the proliferation and differentiation of intermediate progenitors (IPs). Axin-1 is a Wnt signaling pathway scaffold protein that plays a critical role in orchestrating the signals controlling IP population and the number of differentiated neurons during neurogenesis in the developing cerebral cortex. Axin-1 is phosphorylated at Thr485 by Cdk5, the Thr485 phosphorylation results in Axin-1 translocation from the cytoplasm to nucleus upon neuronal progenitor cell (NPC) differentiation. The interaction between cytoplasmic Axin-1 and GSK-3β is critical for the amplification of the undifferentiated IP pool, whereas the interaction between phosphorylated Axin-1 and β-catenin in the nucleus promotes neuronal differentiation. Cdk5-mediated Axin-1 phosphorylation therefore serves as a molecular switch from amplification to differentiation in NPCs.
Immunogen
Linear peptide corresponding to a mouse axin-1 sequence containing phosphorylated Thr485.