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Description
Goat Anti-Rabbit MYH polyclonal antibody for WB. Myosins consist of a large family of motor proteins that interact with the actin filament to generate contractile force. These large structural proteins (520 kDa) can be grouped into approximately 20 classes in eukaryotes on the basis of their sequences in the ATP-hydrolyzing domains. Each myosin assembly contains a pair of myosin heavy chain (220 kDa each) and two pairs of myosin light chain (MYL, 20 kDa each). At least 10 MYH isoforms have been described in mammalian striated, smooth, and non-muscle cells. For instance, the MYH1, 2, 3, 4, 8, and 13 genes encode the skeletal muscle isoforms whereas the MYH6 and MYH7 encode the cardiac muscle isoforms. MYH11 encodes the smooth muscle isoform. MYH9, 10, and 14 encode the non-muscle isoforms.