Purity >98% by HPLC. Potent, selective and non-cytotoxic downstream RUNX modulator. Potently induces the differentiation of human mesenchymal stem cells (hMSCs) into chondrocytes (EC50 = 100 nM). It shows chondroprotective effects in vitro and is efficacious in two Osteoarthritis (OA) animal models. It binds filamin A, disrupts its interaction with the transcription factor core-binding factor Beta subunit (CBFBeta) and induces chondrogenesis by regulating the CBFBeta-RUNX1 transcriptional program.