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Description
DAG1 (Tyr892) Polyclonal Antibody, Cy7 Conjugated. ? Target Background: Dystroglycan is a laminin binding component of the dystrophin-glycoprotein complex which provides a linkage between the subsarcolemmal cytoskeleton and the extracellular matrix. Dystroglycan 1 is a candidate gene for the site of the mutation in autosomal recessive muscular dystrophies. The dramatic reduction of dystroglycan 1 in Duchenne muscular dystrophy leads to a loss of linkage between the sarcolemma and extracellular matrix, rendering muscle fibers more susceptible to necrosis. Dystroglyca
Immunogen
KLH conjugated synthetic phosphopeptide derived from human DAG1 around the phosphorylation site of Tyr892