Immunofluorescence, Immunoprecipitation, Western Blot
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Description
Epitope: NH2-CELLHSRNEGVATPYAA-OH. Fusion: 09/05. This antibody is specific to beta-catenin phosphorylated at Tyr 654. Beta-1 Catenin is a Key downstream component of the canonical Wnt signaling pathway whose function is affected by differential phosphorylation. Specificity tested on Y654F beta-catenin. See mAb PY489-B-catenin for an antibody specific to beta-catenin phosphorylated at Tyr 489. The catenin target of PY489-B-catenin has been described as nuclear-bound, and the target of PY654-B-catenin (IgG) has been described as membrane-bound/cytoplasmic [PMID 25367124].