Immunohistochemistry: 1:200-1:2000, Western Blot: 1:200-1:2000
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Description
MRGPRX2 Polyclonal Antibody. Orphan receptor. Probably involved in the function of nociceptive neurons. May regulate nociceptor function and/or development, including the sensation or modulation of pain. Cortistatin-14 seems to be a high potency ligand at this receptor. Cortistatin has several biological functions including roles in sleep regulation locomotor activity, and cortical function. In receptor-expressing cells, cortistatin-stimulated increases in intracellular Ca(2+) but had no effect on basal or forskolin-stimulated cAMP levels, suggesting that this receptor is G(q)-coupled. Has a limited expression profile, both peripheral and within the central nervous system, with highest levels in dorsal root ganglion.
Immunogen
n/a
Other Names
Mas-related G-protein coupled receptor member X2, MRGPRX2, MAS-related GPR, member X2