Immunocytochemistry: 1:10-1:2000, Immunofluorescence: 1:10-1:2000, Immunoprecipitation: 1:10-1:500, Western Blot: 1:250-1:500
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Description
p300 Monoclonal Antibody (RW128). p300 is a relatively stable, ubiquitously expressed, nuclear phosphoprotein which is conserved among a variety of mammalian species. It is actively synthesized and phosphorylated in both quiescent and proliferating cells. Cyclic AMP-responsive enhancer binding protein (CREB) binding protein (CBP) and p300 are closely related transcriptional coactivators and have been shown to directly interact with many different DNA-binding transcription factors including nuclear hormone receptors, CREB, c-Fos, C-Jun/v-Jun, c-Myb/v-Myb, TFIIB and MyoD. Both CBP and p300 have been shown to display histone acetyltransferase (HAT) activity, capable of acetylating all four core histone particles in nucleosomes. As a result of
Immunogen
n/a
Other Names
CREBBP/EP300 inhibitory protein 1, Cyclic AMP responsive enhancer binding protein, EP300: E1A binding protein p300, RB and P300 binding protein EID 1,