Immunohistochemistry: 1:500-1:2,000, Immunoprecipitation: 2-10 μg/mg lysate, Western Blot: 1:1,000-1:10,000
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Description
p300 Polyclonal Antibody. EP300 encodes the adenovirus E1A-associated cellular p300 transcriptional co-activator protein. p300 is related by sequence to CPB (CREB-binding protein [CREB: cyclic-AMP responsive element binding protein]), and like CPB can stimulate transcription through activation of CREB. This EP300 activity is specifically inhibited by the adenovirus oncoprotein E1A. EP300 has also been identified as a co-activator of HIF1A (hypoxia-inducible factor 1 alpha), and thus plays a role in the stimulation of hypoxia-induced genes such as VEGF.
Immunogen
n/a
Other Names
CREBBP/EP300 inhibitory protein 1, Cyclic AMP responsive enhancer binding protein, EP300: E1A binding protein p300, RB and P300 binding protein EID 1,