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| Antigenic Specificity | SGO2 |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | human |
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| Isotype | n/a |
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| Format | purified |
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| Size | 10 μL |
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| Concentration | n/a |
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| Applications | Immunoprecipitation: 2-5 μg/mg lysate |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | SGO2 Polyclonal Antibody. Cooperates with PPP2CA to protect centromeric cohesin from separase-mediated cleavage in oocytes specifically during meiosis I. Has a crucial role in protecting REC8 at centromeres from cleavage by separase. During meiosis, protects centromeric cohesion complexes until metaphase II/anaphase II transition, preventing premature release of meiosis-specific REC8 cohesin complexes from anaphase I centromeres. Is thus essential for an accurate gametogenesis. May act by targeting PPP2CA to centromeres, thus leading to cohesin dephosphorylation. Essential for recruiting KIF2C to the inner centromere and for correcting defective kinetochore attachments. |
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| Immunogen | n/a |
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| Other Names | SGOL2; Shugoshin-like 2; Shugoshin-2; Tripin |
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| Gene, Accession # | Entrez: 151246; Uniprot: Q562F6 |
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| Catalog # | A301-261A-T |
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| Price | |
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| Order / More Info | SGO2 Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | n/a |
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